Medication Guidance for Mild Allergic Reactions
Allergy experts no longer recommend diphenhydramine (Benadryl).
Cetirizine (Zyrtec) is a safer and more effective antihistamine.
Pediatricians and allergists are no longer recommending diphenhydramine (Benadryl) for simple allergic reactions because of concerns over side effects, lack of efficacy compared to newer over-the-counter antihistamines, and potential risks from chronic use in adults.
For the majority of our patients, we recommend instead, a one time (daily) dose of cetirizine (Zyrtec):
Please remember that in cases of ANAPHYLAXIS, ALWAYS USE EMERGENCY EPINEPHRINE FIRST (cetirizine is NOT a substitute).
Cetirizine (Zyrtec) is a safer and more effective antihistamine.
Pediatricians and allergists are no longer recommending diphenhydramine (Benadryl) for simple allergic reactions because of concerns over side effects, lack of efficacy compared to newer over-the-counter antihistamines, and potential risks from chronic use in adults.
For the majority of our patients, we recommend instead, a one time (daily) dose of cetirizine (Zyrtec):
- 2.5 mg for children 6 months to 2 years
- 5 mg for children 2-5 years old
- 10 mg for children 6+ years of age
Please remember that in cases of ANAPHYLAXIS, ALWAYS USE EMERGENCY EPINEPHRINE FIRST (cetirizine is NOT a substitute).
Allergy experts no longer recommend diphenhydramine (Benadryl).
Cetirizine (Zyrtec) is a safer and more effective antihistamine.
Pediatricians and allergists are no longer recommending diphenhydramine (Benadryl) for simple allergic reactions
because of concerns over side effects, lack of efficacy compared to newer over-the-counter antihistamines, and potential risks from chronic use in adults.
For the majority of our patients, we recommend instead, a one time (daily) dose of cetirizine (Zyrtec):
- 2.5 mg for children 6 months to 2 years
- 5 mg for children 2-5 years old
- 10 mg for children 6+ years of age



