Medication Guidance for Mild Allergic Reactions

Allergy experts no longer recommend diphenhydramine (Benadryl).

Cetirizine (Zyrtec) is a safer and more effective antihistamine.
Pediatricians and allergists are no longer recommending diphenhydramine (Benadryl) for simple allergic reactions  because of concerns over side effects, lack of efficacy compared to newer over-the-counter antihistamines, and potential risks from chronic use in adults.  
 
For the majority of our patients, we recommend instead, a one time (daily) dose of cetirizine (Zyrtec):
  • 2.5 mg for children 6 months to 2 years
  • 5 mg for children 2-5 years old
  • 10 mg for children 6+ years of age
 
Please remember that in cases of ANAPHYLAXIS, ALWAYS USE EMERGENCY EPINEPHRINE FIRST (cetirizine is NOT a substitute).

Allergy experts no longer recommend diphenhydramine (Benadryl).

Cetirizine (Zyrtec) is a safer and more effective antihistamine.
Pediatricians and allergists are no longer recommending diphenhydramine (Benadryl) for simple allergic reactions  because of concerns over side effects, lack of efficacy compared to newer over-the-counter antihistamines, and potential risks from chronic use in adults.  
 
For the majority of our patients, we recommend instead, a one time (daily) dose of cetirizine (Zyrtec):

  • 2.5 mg for children 6 months to 2 years
  • 5 mg for children 2-5 years old
  • 10 mg for children 6+ years of age

 
Please remember that in cases of ANAPHYLAXIS, ALWAYS USE EMERGENCY EPINEPHRINE FIRST (cetirizine is NOT a substitute).